COGNITIVE NEUROSCIENCE AT THE BRAIN IMAGING CENTER FRANKFURT

Electrophysiological correlates of speech production task sets

This study aims at identifying the spectrotemporal dynamics underlying cognitive preparation for speech production and delineating the effective connectivity of involved brain regions. Data are acquired with MEG and electrocorticography. This study is generously supported by the Heinrich and Fritz Riese Foundation.

Johannes Gehrig is primarily responsible for this project that is run in cooperation with Michael Wibral and Volker Seifert, Goethe University Frankfurt and Simon Hanslmayr, University of Birmingham.

Cognitive and language mapping using direct cortical stimulation during awake brain surgery in tumor patients

Using innovative language, speech, and cognitive tests we improve the quality of intraoperative testing for preservation of brain function.

Christian Kell is in charge of this project that is performed in cooperation with Volker Seifert, Department of Neurosurgery, Goethe University Frankfurt and Mitchel Berger, Departement of Neurosurgery, University of California, San Francisco.

Speech and language networks and recovery in patients with brain tumor

We examine patients with brain tumors in speech and language relevant areas before and after surgical resection. Using speech and language fMRI together with linguistic and neuropsychological testing we relate symptoms to anomalies of speech and language networks and their reorganization after surgery.

This project is run by Johann Philipp Zoellner and is funded by the German Research Foundation.

Optimized cognitive testing and invasive recordings in epilepsy patients

Using innovative cognitive tasks we improve the quality of cognitive testing during invasive epilepsy monitoring. We acquire and analyze high quality invasive recordings with and without cortical sitmulation and analyze the impact of epilepsy and stimulation on cognitive networks.

Johann Philipp Zoellner, Johannes Gehrig, Anke Hermsen, and Christian Kell are in charge of this project that is performed in collaboration with Felix Rosenow, Rhein Main Epilepsy Center Frankfurt, and Volker Seifert, Department of Neurosurgery, Goethe University Frankfurt.

Auditory-motor loops during speech perception and production

The MEG study focuses on the functional connectivity between motor and auditory cortices during anticipation of speech recognition and production tasks. This study characterizes the lateralization of oscillatory activity in different frequency bands and should allow drawing conclusions regarding feedforward and feedback processing.

This study is performed by Anna Oliynyk in cooperation with Michael Wibral and is funded by the German Research Foundation.

Oxytoninergic modulation of speech perception and production

This fMRI study investigates oxytocin in its role as a neuromodulator in speech production and perception by studying polymorphism effects and consequences of acute oxytocin administration on neural networks involved in prosody.

This study is performed by Charlotte Vogt in cooperation with Suzana Gispert-Sanchez.

Sensorimotor loops influencing handedness

The combined EEG/MEG and EEG/fMRI studies investigate the spectrotemporal signatures of sensorimotor interactions underlying bimanual movements that may contribute to the development of handedness.

This study is performed by Anja Pflug, Mareike Floegel and Florian Gompf in cooperation with Helmut Laufs and Michael Wibral and is funded by the Neural Coordination Research Focus Frankfurt.

Neural dynamics of manual sound control

A prevailing view in neuroscience sees the purpose of the brain in the production of complex movements. The brain is assumed to “control” its output, the muscle commands, and to “use” sensory feedback to evaluate certain parameters of the resulting movements. In contrast to such motor control theories, control in the sense of Cybernetics gives a different understanding of the purpose and mechanisms of the brain: Control describes a process, whereby certain parameters of the sensed input are kept in proximity to internal references, by appropriately varying the output. What is controlled is essentially the input, not the output of an organism. The sensory input is at the same time the cause and the result of a movement. Using EEG/MEG and fMRI, we test specific predictions of these two frameworks in manual sound control and identify directed interactions between auditory and sensorimotor networks.

This study is performed by Johannes Kasper and is funded by the Polytechnische Gesellschaft Frankfurt.

Diurnal control of behavior

Using fMRI at rest and during different sensorimotor and cognitive tasks, we aim at identifying the mechanisms by which the circadian pacemaker in the human hypothalamus modulates system-specific brain function to elicit diurnal variations in motor and cognitive behavior. We thank the August Scheidel Foundation for financial support.

This project is run by Lorenzo Cordani in cooperation with Celine Vetter and Till Roenneberg, Institute of Medical Psychology, Ludwig Maximilian University, Munich, and Joerg Stehle, Department of Cellular and Molecular Anatomy, Goethe University Frankfurt.

Empirical Aesthetics: Dissociating fact from fiction

Common sense tells us that there is a difference between reality and fiction, but what has yet to be uncovered are the factors that modulate our implicit knowledge of the distinction between what is real and unreal. This basic research of aesthetic perception and evaluation is positioned between the disciplines of psychology, neurosciences, cultural studies and philosophical aesthetics, and is methodologically implemented in an fMRI-study.

This project is performed by Marion Behrens in cooperation with Pascal Nicklas, Institute for Microscopic Anatomy and Neurobiology, Gutenberg University, Mainz.

Collaborating partners

Frank Birklein, Department of Neurology, Mainz University

Christian Fiebach, Department of Psychology, Goethe University Frankfurt

Suzana Gispert-Sanchez, Department of Neurogenetics, Goethe University Frankfurt

Simon Hanslmayr, University of Birmingham

Pavel Hok, Department of Neurology, Pavlacky University Olomouc

Helmut Laufs, Department of Neurology, Kiel University

Antje Meyer, Max Planck Institute for Psycholinguistics, Nijmegen

Pascal Nicklas, Department of Microscopic Anatomy and Neurobiology, Mainz University

Felix Rosenow, Epilepsy Center Rhein Main, Goethe University Frankfurt

Volker Seifert, Department of Neurosurgery, Goethe University Frankfurt

Joerg Stehle, Department of Neuroanatomy, Goethe University Frankfurt

Michael Wibral, Brain Imaging Center, Goethe University Frankfurt