Cognitive and language mapping using direct electrical stimulation during awake brain surgery in tumor patients

Using innovative language, speech, and cognitive tests we improve the quality of intraoperative testing for preservation of brain function.

Christian Kell is in charge of this project that is performed in cooperation with Volker Seifert, Department of Neurosurgery, Goethe University Frankfurt.

Optimized cognitive testing and invasive recordings in epilepsy patients

Using innovative cognitive tasks we improve the quality of cognitive testing during invasive epilepsy monitoring. We acquire and analyze high quality invasive recordings with and without cortical stimulation and analyze the impact of epilepsy and stimulation on cognitive networks.

Johannes Gehrig, Diljit Singh Kajal, Henrik Kabel, Moritz Funk, and Christian Kell are in charge of this project that is performed in collaboration with Felix Rosenow, Rhein Main Epilepsy Center Frankfurt, and Volker Seifert, Department of Neurosurgery, Goethe University Frankfurt.

Cortical representations of prosodic and syntactic structure

Using temporal representational similarity, we try to identify the way the left perisylvian cortex codes prosodic and syntactic structure during listening, speaking and when maintaining sentences in short term memory. The direct electrocorticography data are acqiured during awake brain tumor surgery.

Johannes Gehrig is primarily responsible for this project that is run in cooperation with Antje Meyer and Andrea Martin, Max Planck Institute for Psycholinguistics, Nijmegen.

Brain dynamics in different states of consciousness

Using electrocorticography during the transition from coma to wakefulness in the course of awake surgery we study the dynamics of the neural signal, particularly interregional information transfer.

This study is run by Christina Weismantel and performed in collaboration with Bertram Scheller, Duesseldorf, Georgios Michalareas, Max Planck Institute for Empirical Aesthetics, and Volker Seifert, Department of Neurosurgery, Goethe University Frankfurt.

Oxytoninergic modulation of speech perception and production

This fMRI study investigates oxytocin in its role as a neuromodulator in speech production and perception by studying polymorphism effects and consequences of acute oxytocin administration on neural networks involved in prosody.

This study is performed by Charlotte Vogt in cooperation with Suzana Gispert-Sanchez.

Neural dynamics of manual sound control

A prevailing view in neuroscience sees the purpose of the brain in the production of complex movements. The brain is assumed to “control” its output, the muscle commands, and to “use” sensory feedback to evaluate certain parameters of the resulting movements. In contrast to such motor control theories, control in the sense of Cybernetics gives a different understanding of the purpose and mechanisms of the brain: Control describes a process, whereby certain parameters of the sensed input are kept in proximity to internal references, by appropriately varying the output. What is controlled is essentially the input, not the output of an organism. The sensory input is at the same time the cause and the result of a movement. Using EEG/MEG and fMRI, we test specific predictions of these two frameworks in manual sound control and identify directed interactions between auditory and sensorimotor networks.

This study is performed by Johannes Kasper and is funded by the Polytechnische Gesellschaft Frankfurt.

Time of day-dependent control of behavior

Using fMRI at rest and during different sensorimotor and cognitive tasks, we aim at identifying the mechanisms by which the circadian pacemaker in the human hypothalamus modulates system-specific brain function to elicit diurnal variations in cognition and control of behavior.

This project is run by Lorenzo Cordani in cooperation with Celine Vetter and Till Roenneberg, Institute of Medical Psychology, Ludwig Maximilian University, Munich, and Joerg Stehle, Department of Cellular and Molecular Anatomy, Goethe University Frankfurt.

Empirical Aesthetics: Dissociating fact from fiction

Common sense tells us that there is a difference between reality and fiction, but what has yet to be uncovered are the factors that modulate our implicit knowledge of the distinction between what is real and unreal. This basic research of aesthetic perception and evaluation is positioned between the disciplines of psychology, neurosciences, cultural studies and philosophical aesthetics, and is methodologically implemented in an fMRI-study.

This project is performed by Marion Behrens in cooperation with Pascal Nicklas, Institute for Microscopic Anatomy and Neurobiology, Gutenberg University, Mainz.

Collaborating partners

Frank Birklein, Department of Neurology, Mainz University

Susanne Fuchs, Leibniz Zentrum Allgemeine Sprachwissenschaft Berlin

Anne-Lise Giraud, Université de Genève

Suzana Gispert-Sanchez, Department of Neurogenetics, Goethe University Frankfurt

Sergiu Groppa, Mainz University

Simon Hanslmayr, University of Birmingham

Pavel Hok, Department of Neurology, Pavlacky University Olomouc

Andrea Martin, Max Planck Institute for Psycholinguistics, Nijmegen

Antje Meyer, Max Planck Institute for Psycholinguistics, Nijmegen

Georgios Michalareas, Max Planck Institute for Empirical Aesthetics, Frankfurt

Muthuraman Muthuraman, Mainz University

Katrin Neumann, Wilhelms University Muenster

Pascal Nicklas, Department of Microscopic Anatomy and Neurobiology, Mainz University

Felix Rosenow, Epilepsy Center Rhein Main, Goethe University Frankfurt

Maren Schmidt-Kassow, Institute of Medical Psychology, Goethe University Frankfurt

Volker Seifert, Department of Neurosurgery, Goethe University Frankfurt

Wolf Singer, Ernst Struengmann Institute, Frankfurt

Joerg Stehle, Department of Neuroanatomy, Goethe University Frankfurt

Michael Wibral, Bernstein Venter for Computational Neuroscience, Goettingen